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Synthesis of 2‐Substituted Indoles through Visible Light‐Induced Photocatalytic Cyclizations of Styryl Azides
Author(s) -
Xia XuDong,
Xuan Jun,
Wang Qiang,
Lu LiangQiu,
Chen JiaRong,
Xiao WenJing
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400527
Subject(s) - photocatalysis , chemistry , intramolecular force , photochemistry , visible spectrum , ruthenium , catalysis , combinatorial chemistry , organic chemistry , optoelectronics , materials science
A visible light‐induced photocatalytic intramolecular cyclization of styryl azides has been developed in the presence of the ruthenium complex Ru(bpy) 3 Cl 2 (0.5 mol%) as photocatalyst at room temperature. The present photocatalytic strategy features operational simplicity as well as high functional group tolerance, and provides a facile access to various 2‐substituted N ‐free indoles in good to excellent yields. Importantly, the present process can employ sunlight as the light source to afford the corresponding products without loss of reaction efficiency.