Premium
Direct Synthesis of Pyrrolo[3,4‐ c ]quinolines from the Domino Reaction of Tosylmethyl Isocyanides and Aminochalcones
Author(s) -
Hu Zhongyan,
Li Yifei,
Pan Ling,
Xu Xianxiu
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400468
Subject(s) - chemistry , domino , tandem , cycloaddition , cascade reaction , combinatorial chemistry , isocyanide , tricyclic , stereochemistry , organic chemistry , catalysis , materials science , composite material
A tandem formal [3+2] cycloaddition/cyclization reaction of aminochalcones with tosylmethyl isocyanide derivatives was developed for the practical and convenient synthesis of diverse tricyclic pyrrolo[3,4‐ c ]quinolines in high to excellent yields. In this domino process, three new bonds and two rings are successively formed at ambient conditions.