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Tetrabutylammonium Iodide‐Catalyzed Phosphorylation of Benzyl CH Bonds via a Cross‐Dehydrogenative Coupling (CDC) Reaction
Author(s) -
Xu Jian,
Zhang Pengbo,
Li Xueqin,
Gao Yuzhen,
Wu Ju,
Tang Guo,
Zhao Yufen
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400436
Subject(s) - chemistry , synthon , catalysis , nucleophile , iodide , toluene , phosphate , iodine , organic chemistry , phosphorus , combinatorial chemistry , medicinal chemistry
Phosphate esters play important roles as biological active principles and synthons in chemistry. An efficient metal‐free approach for the synthesis of phosphate esters through sp 3 CH activation is described. By using tetrabutylammonium iodide (Bu 4 NI) as a catalyst and tert ‐butyl hydroperoxide (TBHP) as an oxidant, various toluene derivatives and phosphorus nucleophiles are tolerated in this transformation, affording the corresponding products in moderate to good yields.