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Asymmetric Synthesis of α‐Amino Acids under Operationally Convenient Conditions
Author(s) -
Jörres Manuel,
Chen Xia,
Aceña José Luis,
Merkens Carina,
Bolm Carsten,
Liu Hong,
Soloshonok Vadim A.
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400405
Subject(s) - chemistry , reagent , aldol reaction , amino acid , alkyl , halide , glycine , organic chemistry , combinatorial chemistry , enantioselective synthesis , catalysis , biochemistry
A new multipurpose glycine equivalent for the general asymmetric synthesis of α‐amino acids is introduced. The chiral reagent can be transformed to various amino acids by alkylations with alkyl halides as well as aldol and Michael addition reactions under operationally convenient reaction conditions at room temperature with virtually complete stereochemical control.