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Organocatalysis in Enantioselective α‐Functionalization of 2‐Cyanoacetates
Author(s) -
DíazdeVillegas María D.,
Gálvez José A.,
Badorrey Ramón,
LópezRamdeVíu Pilar
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400404
Subject(s) - enantioselective synthesis , chemistry , organocatalysis , surface modification , nucleophile , alkylation , conjugate , organic chemistry , mannich reaction , michael reaction , combinatorial chemistry , catalysis , mathematical analysis , mathematics
Recent progress in asymmetric organocatalysis has led to the development of several asymmetric transformations that employ various substrates. Among these, cyanoacetates have emerged as excellent nucleophiles in conjugate addition, alkylation, Mannich and α‐heterofunctionalization reactions. In this review we discuss the enantioselective functionalization of 2‐cyanoacetates through organocatalytic reactions.