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Application of Langlois’ Reagent in Trifluoromethylation Reactions
Author(s) -
Zhang Cai
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400370
Subject(s) - trifluoromethylation , chemistry , reagent , trifluoromethyl , organic chemistry , alkyl
The incorporation of a trifluoromethyl (CF 3 ) group into organic compounds is of great importance in pharmaceutical, agricultural, and materials science. Trifluoromethylation based on radical intermediates, as a valuable alternative transformation using the inexpensive and stable solid sodium trifluoromethanesulfinate (CF 3 SO 2 Na; Langlois’ reagent), has attracted much attention and has become a hot research field. This review examines recent advances in radical trifluoromethylation reactions with CF 3 SO 2 Na as CF 3 source.