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Thioesterification of Alkylbenzenes with Thiols via Copper‐ Catalyzed Cross‐Dehydrogenative Coupling without a Directing Group
Author(s) -
Ali Wajid,
Guin Srimanta,
Rout Saroj Kumar,
Gogoi Anupal,
Patel Bhisma K.
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400360
Subject(s) - alkylbenzenes , chemistry , thioester , moiety , thiol , copper , functional group , catalysis , group (periodic table) , medicinal chemistry , organic chemistry , combinatorial chemistry , polymer chemistry , stereochemistry , enzyme , polymer
A unique copper‐catalyzed cross‐dehydrogenative coupling (CDC) of thiols and alkylbenzenes has been developed for the synthesis of thioesters without the assistance of any directing group. A thioester moiety is created via successive CS and CO bond formation at the expense of three sp 3 CH bonds of the alkylbenzene and one sp 3 SH bond of the thiol.