Metal‐Free 2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ)‐Mediated Cross‐Dehydrogenative‐Coupling (CDC) of Benzylic C( sp  3 )H Bonds and Vinylic C( sp  2 )H Bonds: Efficient One‐Pot Synthesis of 1 H ‐Indenes | Zendy

Wang He | Zendy; Zhao YuLong | Zendy; Li Lei | Zendy; Li ShaSha | Zendy; Liu Qun | Zendy

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Metal‐Free 2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ)‐Mediated Cross‐Dehydrogenative‐Coupling (CDC) of Benzylic C( sp 3 )H Bonds and Vinylic C( sp 2 )H Bonds: Efficient One‐Pot Synthesis of 1 H ‐Indenes

Author(s) -

Wang He,

Zhao YuLong,

Li Lei,

Li ShaSha,

Liu Qun

Publication year - 2014

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201400357

Subject(s) - chemistry , benzoquinone , intermolecular force , heteroatom , medicinal chemistry , alkyl , double bond , stereochemistry , coupling reaction , photochemistry , molecule , polymer chemistry , organic chemistry , catalysis

A novel 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ)‐promoted intermolecular cross‐dehydrogenative coupling reaction of alkyl C( sp 3 )H bonds not adjacent to heteroatoms with vinylic C( sp 2 )H bonds has been developed. This new strategy provides a new, environmentally friendly, and efficient protocol for the synthesis of polysubstituted 1 H ‐indenes in a single step via a radical‐initiated two C( sp 2 )C( sp 2 ) and C( sp 2 )C( sp 3 ) bond formation process.

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