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Cooperative Catalysis with Iron and a Chiral Brønsted Acid for Asymmetric Reductive Amination of Ketones
Author(s) -
Zhou Shaolin,
Fleischer Steffen,
Jiao Haijun,
Junge Kathrin,
Beller Matthias
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400328
Subject(s) - reductive amination , chemistry , brønsted–lowry acid–base theory , catalysis , amination , organic chemistry , enantioselective synthesis , organocatalysis , hydrogen , combinatorial chemistry
The direct asymmetric reductive amination (DARA) of ketones with anilines is described by combining a chiral Brønsted acid (TRIP) and the non‐chiral Knölker iron complex as the catalyst system. In situ‐ formed imines are reduced with molecular hydrogen to give chiral amines in high yields (90%) and enantioselectivities of up to 99% ee .