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One‐Pot Double Benzylation of 2‐Substituted Pyridines using Palladium‐Catalyzed Decarboxylative Coupling of sp 2 and sp 3 Carbons
Author(s) -
Wang Yaping,
Li Xinjian,
Leng Faqiang,
Zhu Helong,
Li Jingya,
Zou Dapeng,
Wu Yangjie,
Wu Yusheng
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400311
Subject(s) - chemistry , palladium , picolinic acid , catalysis , bimetallic strip , decarboxylation , chloride , oxide , organic chemistry , medicinal chemistry
An efficient and practical decarboxylative double benzylation method for various 2‐picolinic acids has been established by using a bimetallic catalytic system of palladium(II) chloride (PdCl 2 ) and silver(I) oxide (Ag 2 O), which offered a variety of diarylmethane derivatives with moderate to good yields.