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Enantioselective Heterogeneous Synergistic Catalysis for Asymmetric Cascade Transformations
Author(s) -
Deiana Luca,
Ghisu Lorenza,
Afewerki Samson,
Verho Oscar,
Johnston Eric V.,
Hedin Niklas,
Bacsik Zoltan,
Córdova Armando
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400291
Subject(s) - enantioselective synthesis , chemistry , catalysis , electrophile , nucleophile , cascade , combinatorial chemistry , cascade reaction , modular design , stereochemistry , organic chemistry , chromatography , computer science , operating system
A modular design for a novel heterogeneous synergistic catalytic system, which simultaneously activates the electrophile and nucleophile by the combined activation modes of a separate metal and non‐metal catalyst, for asymmetric cascade transformations on a solid surface is disclosed. This modular catalysis strategy generates carbocycles (up to 97.5:2.5 er ) as well as spirocyclic oxindoles (97.5:2.5 to >99:0.5 er ), containing all‐carbon quaternary centers, in a highly enantioselective fashion via a one‐pot dynamic relay process.