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Photo‐Assisted Multi‐Component Reactions (MCR): A New Entry to 2‐Pyrimidinethiones
Author(s) -
Guo Haiheng,
Zhu Chenghao,
Li Jian,
Xu Guangyang,
Sun Jiangtao
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400290
Subject(s) - chemistry , component (thermodynamics) , condensation , combinatorial chemistry , condensation reaction , reaction conditions , multi component reaction , organic chemistry , catalysis , thermodynamics , physics
A photo‐assisted metal‐free multi‐component dehydrogenative condensation has been developed. This multi‐component reaction (MCR) has been realized under mild reaction conditions especially under household light irradiation. As a result, the novel tetrahydropyrimidines (THPMs) were obtained in moderate yields and excellent stereoselectivities. Moreover, the approach provided an easy construction of a variety of 2‐pyrimidinethiones from the commonly used cyclic ethers.