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Enantioselective Intramolecular Hydroamination of Unactivated Alkenes Catalyzed by Mono‐ and Bis(gold) Phosphine Complexes
Author(s) -
Lee Seong Du,
Timmerman Jacob C.,
Widenhoefer Ross A.
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400268
Subject(s) - hydroamination , chemistry , intramolecular force , enantioselective synthesis , phosphine , pyrrolidine , catalysis , organic chemistry , tetrafluoroborate , medicinal chemistry , ionic liquid
A 1:2 mixture of ( P1 )(AuCl) 2 [ P1 =( S )‐DTBM‐MeO‐BIPHEP] and silver tetrafluoroborate (AgBF 4 ) in methanol catalyzes the intramolecular hydroamination of unactivated alkenes with carbamates and ureas to form pyrrolidine derivatives with up to 85% ee .
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