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ansa ‐Ruthenium(II) Complexes of DPEN‐SO 2 N(Me)(CH 2 ) n (η 6 ‐aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones
Author(s) -
Kišić Andrea,
Stephan Michel,
Mohar Barbara
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400265
Subject(s) - chemistry , ruthenium , enantiopure drug , transfer hydrogenation , aryl , triethylamine , catalysis , formic acid , medicinal chemistry , alkyl , organic chemistry , enantioselective synthesis
A diversified ansa ‐ruthenium(II) catalyst series 1b–f displaying enantiopure N , C ‐( N ‐alkylene‐ N ‐methylsulfamoyl)‐tethered (DPEN‐κ 2 N , N ′)/η 6 ‐arene (DPEN= trans ‐1,2‐diphenylethylenediamine) hybrid ligands was screened in the transfer hydrogenation of alkyl aryl ketones, and α‐ or β‐diketones in formic acid‐triethylamine (HCO 2 H‐Et 3 N) medium under mild conditions and furnished the alcohols in high to excellent ee s.