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Ferrocenyl‐Based P,N Catalysts for the Mono‐α‐Arylation of Acetone
Author(s) -
Gäbler Christian,
Korb Marcus,
Schaarschmidt Dieter,
Hildebrandt Alexander,
Lang Heinrich
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400235
Subject(s) - chemistry , acetone , palladium , catalysis , medicinal chemistry , coupling (piping) , combinatorial chemistry , organic chemistry , metallurgy , materials science
The novel air‐stable diferrocenyl‐based P,N ligands PFc 2 (C 6 H 4 ‐2‐NMe 2 ) ( 1 ) and PFc 2 (C 6 H 4 ‐2‐piperidyl) ( 2 ) [Fc=Fe(η 5 ‐C 5 H 4 )(η 5 ‐C 5 H 5 )] for the highly effective palladium‐catalyzed mono‐α‐arylation of acetone are reported. High yields could be obtained for the CC coupling of several chloro‐ and bromoarenes at palladium loadings as low as 0.5 mol% of [Pd(cinnamyl)Cl] 2 .