Stable Nickel(0) Phosphites as Catalysts for CN Cross‐Coupling Reactions | Zendy

Kampmann Sven S. | Zendy; Sobolev Alexandre N. | Zendy; Koutsantonis George A. | Zendy; Stewart Scott G. | Zendy

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Stable Nickel(0) Phosphites as Catalysts for CN Cross‐Coupling Reactions

Author(s) -

Kampmann Sven S.,

Sobolev Alexandre N.,

Koutsantonis George A.,

Stewart Scott G.

Publication year - 2014

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201400201

Subject(s) - chemistry , nickel , catalysis , amination , palladium , ferrocene , aryl , coupling reaction , organic chemistry , polymer chemistry , medicinal chemistry , electrochemistry , alkyl , electrode

Herein we describe the design and preparation of inexpensive, air‐stable nickel phosphite‐based catalysts for use in the CN cross‐coupling reaction. The combination of nickel tetrakis(triphenyl phosphite) {Ni[P(OPh) 3 ] 4 } and 1,1′‐bis(diphenylphosphino)ferrocene (dppf), and in particular a newly developed catalyst (dppf)Ni[P(OPh) 3 ] 2 , were found to be extremely effective in catalyzing a range of amination reactions of anilines and amines with aryl chlorides. This new catalyst system offers an alternative to the bis(cyclooctadienyl)nickel [Ni(COD) 2 ] and palladium(0) catalysts commonly used for CN bond formation.

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