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Stable Nickel(0) Phosphites as Catalysts for CN Cross‐Coupling Reactions
Author(s) -
Kampmann Sven S.,
Sobolev Alexandre N.,
Koutsantonis George A.,
Stewart Scott G.
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400201
Subject(s) - chemistry , nickel , catalysis , amination , palladium , ferrocene , aryl , coupling reaction , organic chemistry , polymer chemistry , medicinal chemistry , electrochemistry , alkyl , electrode
Herein we describe the design and preparation of inexpensive, air‐stable nickel phosphite‐based catalysts for use in the CN cross‐coupling reaction. The combination of nickel tetrakis(triphenyl phosphite) {Ni[P(OPh) 3 ] 4 } and 1,1′‐bis(diphenylphosphino)ferrocene (dppf), and in particular a newly developed catalyst (dppf)Ni[P(OPh) 3 ] 2 , were found to be extremely effective in catalyzing a range of amination reactions of anilines and amines with aryl chlorides. This new catalyst system offers an alternative to the bis(cyclooctadienyl)nickel [Ni(COD) 2 ] and palladium(0) catalysts commonly used for CN bond formation.