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Rhodium‐Catalyzed Direct Oxidative CH Acylation of 2‐Arylpyridines with Terminal Alkynes: A Synthesis of Pyrido[2,1‐ a ]isoindoles
Author(s) -
Zhao Binlin,
Yu Mengxuan,
Liu Hui,
Chen Yu,
Yuan Yu,
Xie Xuejian
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400198
Subject(s) - rhodium , chemistry , acylation , catalysis , aryl , oxidative phosphorylation , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , alkyl
A synthesis of pyrido[2,1‐ a ]isoindoles is reported by the rhodium‐catalyzed direct oxidative CH acylation of 2‐aryl pyridines with terminal alkynes. The desired products were obtained in moderate to excellent yields. This is an efficient and clean method to construct CC/CN bonds in one step. In addition, the effective rhodium(III) catalyst was isolated and characterized by X‐ray crystallography.