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Palladium‐Catalyzed Hydrophosphonylation of Alkenes with Dialkyl H‐Phosphonates
Author(s) -
Candy Mathieu,
Rousseaux Sophie A. L.,
San Román Alberto Cirugeda,
Szymczyk Monika,
Kafarski Pawel,
Leclerc Eric,
Vrancken Emmanuel,
Campagne JeanMarc
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400190
Subject(s) - palladium , regioselectivity , catalysis , chemistry , organic chemistry , medicinal chemistry
The palladium‐catalyzed hydrophosphonylation of alkenes with previously unreactive acyclic dialkyl H‐phosphonates has been developed. A catalyst system based on palladium/DavePhos or palladium/SPhos enables the transformation of various alkenes to phosphonates in moderate to good yields and with excellent levels of regioselectivity. Hydrophosphonylations with internal, disubstituted and/or unactivated alkenes are also reported.