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Cover Picture: (Adv. Synth. Catal. 5/2014)
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400156
Subject(s) - chemistry , regioselectivity , indole test , indoline , moiety , iridium , front cover , substituent , alkylation , ring (chemistry) , stereochemistry , combinatorial chemistry , catalysis , organic chemistry , cover (algebra) , mechanical engineering , engineering
The front cover picture , was provided by Takanori Shibata. Indole is a core skeleton in many biologically active compounds; therefore, direct and regioselective installation of substituent(s) to the indole ring is an important protocol. We have developed a C‐7 alkylation of N ‐substituted indoline derivatives with various alkenes using a cationic iridium catalyst. This CH bond activation relies on the use of the carbonyl moiety as a directing group and it is potentially applicable to the synthesis of 7‐alkylindoles as well as 7‐alkylindolines. The details are disclosed in the Communication on pages 929–933 (S. Pan, N. Ryu, and T. Shibata, Adv. Synth. Catal. 2014, 356, 929–933; DOI: 10.1002/adsc.201300917 ).