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Palladium‐Catalyzed Intermolecular Allylic Dearomatization Reaction of α‐Substituted β‐Naphthol Derivatives: Scope and Mechanistic Investigation
Author(s) -
Zhuo ChunXiang,
You ShuLi
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400154
Subject(s) - chemistry , chemoselectivity , regioselectivity , catalysis , palladium , organic chemistry , allylic rearrangement , intermolecular force , tsuji–trost reaction , 1 naphthol , combinatorial chemistry , scope (computer science) , alkylation , molecule , computer science , programming language
A highly efficient dearomatization reaction of α‐substituted β‐naphthols with excellent chemoselectivity and regioselectivity has been developed. Mechanistic studies demonstrated that the dearomatized alkylation product is the thermodynamically more stable compound. The etherification product could be further transformed to the dearomatization product.