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The Oxidative Annulation of Tertiary Benzyl Alcohols with Internal Alkynes using an (Electron‐Deficient η 5 ‐Cyclopenta‐ dienyl)Rhodium(III) Catalyst under Ambient Conditions
Author(s) -
Fukui Miho,
Hoshino Yuki,
Satoh Tetsuya,
Miura Masahiro,
Tanaka Ken
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400084
Subject(s) - annulation , rhodium , chemistry , catalysis , cyclopentadienyl complex , electron , oxidative phosphorylation , medicinal chemistry , photochemistry , organic chemistry , biochemistry , physics , quantum mechanics
It has been established that a dinuclear (electron‐deficient η 5 ‐cyclopentadienyl)rhodium(III) complex catalyzes the oxidative annulation of tertiary benzyl alcohols with internal alkynes via sp 2 CH/OH functionalization under ambient conditions (at room temperature under air) to give substituted isochromenes in good yields. The preference for annulation across electron‐rich substrates over electron‐deficient substrates was observed using this electron‐deficient rhodium(III) complex.