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Intramolecular Direct Arylation and Heck Reactions in the Formation of Medium‐Sized Rings: Selective Synthesis of Fused Indolizine, Pyrroloazepine and Pyrroloazocine Systems
Author(s) -
Coya Estibaliz,
Sotomayor Nuria,
Lete Esther
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400075
Subject(s) - indolizine , chemistry , intramolecular force , pyrrole , catalysis , heck reaction , alkene , palladium , combinatorial chemistry , halide , bromobenzene , ring (chemistry) , cascade reaction , photochemistry , medicinal chemistry , organic chemistry
The intramolecular palladium‐catalyzed reaction of N ‐(iodoarylalkyl)pyrroles can be applied for the selective synthesis of medium‐sized rings by choosing the appropriate catalytic systems to direct the reaction to the alkene or to the pyrrole nucleus. These reactions can also be extended to the corresponding heteroaryl halides. Thus, reaction conditions have been established to access selectively to (hetero)fused indolizine, pyrroloazepine and pyrroloazocine systems.