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Arylation of Azlactones using Diaryliodonium Bromides and Silver Carbonate: Facile Access to α‐Tetrasubstituted Amino Acid Derivatives
Author(s) -
Chai Zhuo,
Wang Biao,
Chen JiaNan,
Yang Gaosheng
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400035
Subject(s) - chemistry , aryl , alkyl , carbonate , amino acid , organic chemistry , combinatorial chemistry , reaction conditions , catalysis , biochemistry
With the combined use of silver carbonate, diaryliodonium bromides were successfully utilized as aryl source to realize the highly efficient arylation of azlactones under mild conditions. The reaction worked well with various alkyl‐ and aryl‐substituted azlactones, providing a range of α‐tetrasubstituted amino acid derivatives in moderate to high yields.