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Metal‐Free Preparation of Cycloalkyl Aryl Sulfides via Di‐ tert ‐butyl Peroxide‐Promoted Oxidative C( sp 3 )H Bond Thiolation of Cycloalkanes
Author(s) -
Zhao Jincan,
Fang Hong,
Han Jianlin,
Pan Yi,
Li Guigen
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400032
Subject(s) - chemistry , aryl , peroxide , catalysis , double bond , medicinal chemistry , oxidative addition , organic chemistry , metal , polymer chemistry , alkyl
Abstract A concise thiolation of the C( sp 3 )H bond of cycloalkanes with diaryl disulfides in the presence of the oxidant di‐ tert ‐butyl peroxide (DTBP) has been developed. This reaction, without using any metal catalyst, tolerates varieties of disulfides and cycloalkanes substrates, giving good to excellent chemical yields, and thus provides a useful approach to cycloalkyl aryl sulfides from unactivated cycloalkanes.