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Carboxylate‐Directed CH Functionalization
Author(s) -
Shi Guangfa,
Zhang Yanghui
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400028
Subject(s) - chemistry , surface modification , carboxylate , transition metal , catalysis , heteroatom , molecule , carbon fibers , functional group , combinatorial chemistry , organic chemistry , polymer , ring (chemistry) , materials science , composite number , composite material
As a widely existing functional group in organic molecules, the carboxyl group has numerous advantageous characteristics such as great convenience for further transformation, relatively low toxicity and cost, and weak coordination to transition metal catalysts, which render it an attractive directing group in transition metal‐catalyzed CH bond functionalization reactions. This review surveys transition metal‐catalyzed CH bond functionalization reactions directed by carboxylates, including carbon‐carbon, carbon‐oxygen, and other carbon‐heteroatom bond formation reactions. Reactions directed by the acidic N ‐arylamides, which are derived from carboxylic acids and have a directing mode similar to that of carboxylates, are also presented here.