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Cover Picture: (Adv. Synth. Catal. 14‐15/2013)
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201390029
Subject(s) - chemistry , phloretin , glycosyltransferase , glycosylation , natural product , glucosyltransferase , uridine diphosphate , stereochemistry , organic chemistry , biochemistry , enzyme
C‐Glycosyltransferases and Natural Product Glycosylation The front cover picture, provided by Linda Bungaruang, Alexander Gutmann and Bernd Nidetzky, illustrates the production of the C ‐glucoside nothofaginin a onepot synthesis by coupling two glucosyltransferase activities. The dihydrochalcone acceptor phloretin is selectively C ‐glucosylated at position 3′ by C ‐glucosyltransferase using uridine 5′‐diphosphate (UDP)‐glucose as sugar donor which is continuously formed in situ from sucrose and catalytic amounts of UDP using sucrose synthase. Best yields were obtained using periodic feeding of the poorly water‐soluble phloretin, resulting in intensification of glycoside formation by up to three orders of magnitude in relation to comparable glycosylations in natural product synthesis. This methodology is illustrated in the communication by Bungaruang, Gutmann and Nidetzky on pages 2757–2763 ( DOI: 10.1002/adsc.201300251 ).