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Cover Picture: (Adv. Synth. Catal. 7/2013)
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201390011
Subject(s) - chemistry , bicyclic molecule , intramolecular force , cycloaddition , alkene , michael reaction , cover (algebra) , ring (chemistry) , alkylation , stereochemistry , organic chemistry , catalysis , mechanical engineering , engineering
The cover picture, provided by De Miguel, Velado, Herradón and Mann, describes the process for the synthesis of functionalized bicyclic imines from readily available ω ‐azidodienes through a cascade reaction sequence. The transformation is highly selective and involves an intramolecularazide‐alkene 1,3‐dipolar cycloaddition, followed by an intramolecular Michael addition of the resulting five‐ or sixmembered ring cyclic enamines to different Michael acceptors (Stork alkylation), to afford the corresponding bicyclic imines in moderate to good yields. This methodology is illustrated in the communication by Mann and co‐workers on pages 1237–1242.