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Inside Front Cover: Asymmetric Aldol Reaction of 3‐Acetyl‐2 H ‐chromen‐2‐ones and Isatins Catalyzed by a Bifunctional Quinidine Urea Catalyst (Adv. Synth. Catal. 1/2014)
Author(s) -
Abbaraju Santhi,
Zhao John CongGui
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201301177
Subject(s) - chemistry , bifunctional , moiety , aldol reaction , catalysis , yield (engineering) , isatin , urea , medicinal chemistry , amination , combinatorial chemistry , nitroaldol reaction , organic chemistry , enantioselective synthesis , materials science , metallurgy
The inside cover picture, provided by Santhi Abbaraju and John Cong‐Gui Zhao, illustrates the catalytic action of a quinidine‐derived urea catalyst in the title reaction. The bifunctional catalyst enolizes 3‐acetyl‐ 2H ‐chromen‐2‐one using its Brnsted base moiety and simultaneously activates isatin through hydrogen bonding using its urea moiety. Such synergistic actions yield the corresponding aldol product, which is difficult to obtain via other methods due to its labile nature, in high yield and enantioselectivity, as is reported in the update by Santhi Abbaraju and John Cong‐Gui Zhao on pages 237–241 (DOI: "10.1002/adsc.201300623) .