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An Unexpected Addition of Acetic Acid to ortho ‐Electron‐ Deficient Alkynyl‐Substituted Aryl Aldehydes Catalyzed by Palladium(II) Acetate
Author(s) -
Zhang Jianbo,
Han Xiuling
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201301170
Subject(s) - chemistry , acetic acid , palladium , aryl , catalysis , palladium(ii) acetate , medicinal chemistry , organic chemistry , alkyl
An unexpected addition of acetic acid to ortho ‐electron‐deficient alkynyl‐substituted aryl aldehydes catalyzed by palladium(II) acetate was achieved, which provided a convenient method for the synthesis of dihydroisobenzofurans in moderate to good yields. The electron‐withdrawing groups attached to alkynes may play an important role for the cyclization.