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Synthesis of Diverse Azolo[ c ]quinazolines by Palladium(II)‐ Catalyzed Aerobic Oxidative Insertion of Isocyanides
Author(s) -
Vlaar Tjøstil,
Bensch Lisa,
Kraakman Jasper,
Vande Velde Christophe M. L.,
Maes Bert U. W.,
Orru Romano V. A.,
Ruijter Eelco
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201301129
Subject(s) - chemistry , palladium , oxidative phosphorylation , catalysis , stoichiometry , combinatorial chemistry , oxidative coupling of methane , organic chemistry , biochemistry
We report the palladium(II)‐catalyzed aerobic oxidative coupling of isocyanides with various (2‐aminophenyl)azoles using air as the stoichiometric oxidant. A diverse range of medicinally valuable azolo[ c ]quinazolines was obtained by this new approach.