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Chemoselective Ruthenium‐Catalysed Reduction of Carboxylic Acids
Author(s) -
FernándezSalas José A.,
Manzini Simone,
Nolan Steven P.
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201301088
Subject(s) - chemistry , ruthenium , carboxylic acid , catalysis , benzoic acid , reduction (mathematics) , organic chemistry , combinatorial chemistry , chemoselectivity , geometry , mathematics
A very general and efficient catalytic protocol for the selective reduction of carboxylic acids to their corresponding alcohols under mild conditions is described. Various carboxylic acids, including benzoic acids, were reduced in good yields using the presented methodology. The ruthenium‐catalysed method yields a highly chemoselective reduction permitting the reduction of a carboxylic acid functionality in the presence of numerous other potentially reducible moieties.