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H‐Phosphonate‐Mediated Amination of Quinoline N ‐Oxides with Tertiary Amines: A Mild and Metal‐Free Synthesis of 2‐Dialkylaminoquinolines
Author(s) -
Chen Xiaolan,
Li Xu,
Qu Zhibo,
Ke Diandian,
Qu Lingbo,
Duan Likun,
Mai Wenpeng,
Yuan Jinwei,
Chen Jianyu,
Zhao Yufen
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201301065
Subject(s) - chemistry , phosphonate , quinoline , amination , reductive amination , carbon tetrachloride , metal , combinatorial chemistry , organic chemistry , polymer chemistry , catalysis
A synthetic strategy has been developed for the synthesis of 2‐dialkylaminoquinolines from easily available quinoline N ‐oxides, tertiary amines, diisopropyl H‐phosphonate and carbon tetrachloride (CCl 4 ) in one pot under metal‐free conditions at room temperature.