Premium
One‐Pot Synthesis of Triazoloquinazolinones via Copper‐ Catalyzed Tandem Click and Intramolecular CH Amidation
Author(s) -
Selvaraju Manikandan,
Sun ChungMing
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201301013
Subject(s) - chemistry , intramolecular force , tandem , catalysis , combinatorial chemistry , copper , substrate (aquarium) , click chemistry , ligand (biochemistry) , cascade reaction , stereochemistry , organic chemistry , receptor , biochemistry , materials science , oceanography , composite material , geology
A novel and highly efficient copper‐catalyzed tandem synthesis of triazoloquinazolinones is explored. The synthetic strategy involves a sequential one‐pot click reaction followed by aerobic intramolecular CH amidation. Two distinct and important transformations were carried out in one‐pot by employing a single cost‐effective copper catalyst. The milder, rapid and ligand‐free reaction conditions as well as a broader substrate scope are the salient features of this novel protocol.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom