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One‐Pot Synthesis of Triazoloquinazolinones via Copper‐ Catalyzed Tandem Click and Intramolecular CH Amidation
Author(s) -
Selvaraju Manikandan,
Sun ChungMing
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201301013
Subject(s) - chemistry , intramolecular force , tandem , catalysis , combinatorial chemistry , copper , substrate (aquarium) , click chemistry , ligand (biochemistry) , cascade reaction , stereochemistry , organic chemistry , receptor , biochemistry , materials science , oceanography , composite material , geology
A novel and highly efficient copper‐catalyzed tandem synthesis of triazoloquinazolinones is explored. The synthetic strategy involves a sequential one‐pot click reaction followed by aerobic intramolecular CH amidation. Two distinct and important transformations were carried out in one‐pot by employing a single cost‐effective copper catalyst. The milder, rapid and ligand‐free reaction conditions as well as a broader substrate scope are the salient features of this novel protocol.