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Copper Pincer Complexes as Advantageous Catalysts for the Heteroannulation of ortho ‐Halophenols and Alkynes
Author(s) -
Moure María Jesús,
SanMartin Raul,
Domínguez Esther
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201301010
Subject(s) - chemistry , benzofuran , pincer movement , catalysis , intramolecular force , copper , halogen , homogeneous , homogeneous catalysis , photochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl , physics , thermodynamics
A new, non‐symmetrical copper(II) pincer complex catalyzes much more efficiently the formation of benzofuran by the reaction between ortho ‐iodophenols and alkynes. The lowest catalyst loadings are realized for this reaction, and bromo‐ and chlorophenols are heteroannulated for the first time. Strong evidence for hydrophenoxylation and intramolecular halogen atom‐transfer steps catalyzed by this remarkably active, recyclable homogeneous catalyst is provided.