Premium
A General Approach towards Catechol and Pyrogallol through Ruthenium‐ and Palladium‐Catalyzed CH Hydroxylation by Weak Coordination
Author(s) -
Yang Xinglin,
Sun Yonghui,
Chen Zhang,
Rao Yu
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300999
Subject(s) - chemistry , chemoselectivity , ruthenium , hydroxylation , palladium , catalysis , catechol , aryl , combinatorial chemistry , pyrogallol , organic chemistry , enzyme , alkyl
An efficient ruthenium(II)‐ and palladium(II)‐catalyzed CH hydroxylation of aryl carbamates has been developed for the facile synthesis of catechols and pyrogallols. The reaction demonstrates excellent reactivity, regio‐ and chemoselectivity, good functional group compatibility and high yields. The practicality of this method has been proved by a gram‐scale synthesis.