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The Iron(II) Complex [Fe(CF 3 SO 3 ) 2 (mcp)] as a Convenient, Readily Available Catalyst for the Selective Oxidation of Methylenic Sites in Alkanes
Author(s) -
Canta Mercè,
Font David,
Gómez Laura,
Ribas Xavi,
Costas Miquel
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300923
Subject(s) - chemistry , catalysis , alkane , hydrogen peroxide , cyclohexane , redox , reaction conditions , combinatorial chemistry , inorganic chemistry , organic chemistry
The efficient and selective oxidation of secondary CH sites of alkanes is achieved by using low catalyst loadings of a non‐expensive, readily available iron catalyst [Fe(II)(CF 3 SO 3 ) 2 (mcp)], { Fe‐mcp , [mcp= N , N′‐ dimethyl‐ N , N′ ‐bis(2‐pyridylmethyl)cyclohexane‐ tran s‐1,2‐diamine]}, and hydrogen peroxide (H 2 O 2 ) as oxidant, via a simple reaction protocol. Natural products are selectively oxidized and isolated in synthetically amenable yields. The easy access to large quantities of the catalyst and the simplicity of the CH oxidation procedure make this system a particularly convenient tool to carry out alkane CH oxidation reactions on the preparative scale, and in short reaction times.