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Cross‐Coupling of Heteroarenes by CH Functionalization: Recent Progress towards Direct Arylation and Heteroarylation Reactions Involving Heteroarenes Containing One Heteroatom
Author(s) -
Rossi Renzo,
Bellina Fabio,
Lessi Marco,
Manzini Chiara
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300922
Subject(s) - chemistry , aryl , heteroatom , intramolecular force , catalysis , transition metal , combinatorial chemistry , reagent , coupling reaction , halide , surface modification , organic chemistry , ring (chemistry) , alkyl
In recent years, transition metal‐catalyzed direct (hetero)arylation reactions of heteroarenes with (hetero)aryl halides and pseudohalides have received significant attention as eco‐friendly and economic alternatives to classical methods for the construction of heteroaryl‐(hetero)aryl CC bonds by transition metal‐catalyzed cross‐couplings involving the use of stoichiometric amounts of organometallic reagents. This critical review with 430 references covers the results obtained in the period January 2009 to February 2013 in the area of the transition metal‐catalyzed direct inter‐ and intramolecular (hetero)arylation reactions of heteroarenes containing one heteroatom. Particular attention has been given to illustrate chemo‐ and site selectivity aspects of these reactions as well applications of these CC bond forming reactions in the synthesis of pharmaceutically relevant compounds, natural products and their analogues and precursors. The most recent advancements into the mechanism(s) of these reactions have also been briefly reported.