Copper(II)‐Catalyzed Aerobic Oxidative Coupling between Chalcone and 2‐Aminopyridine  via  CH Amination: An Expedient Synthesis of 3‐Aroylimidazo[1,2‐ a ]pyridines | Zendy

Monir Kamarul | Zendy; Kumar Bagdi Avik | Zendy; Mishra Subhajit | Zendy; Majee Adinath | Zendy; Hajra Alakananda | Zendy

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Copper(II)‐Catalyzed Aerobic Oxidative Coupling between Chalcone and 2‐Aminopyridine via CH Amination: An Expedient Synthesis of 3‐Aroylimidazo[1,2‐ a ]pyridines

Author(s) -

Monir Kamarul,

Kumar Bagdi Avik,

Mishra Subhajit,

Majee Adinath,

Hajra Alakananda

Publication year - 2014

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201300900

Subject(s) - chemistry , amination , oxidative phosphorylation , intramolecular force , catalysis , regioselectivity , 2 aminopyridine , organic chemistry , oxidative coupling of methane , combinatorial chemistry , copper , tandem , biochemistry , materials science , composite material

A simple and efficient protocol has been developed for the synthesis of 3‐aroylimidazopyridines via copper(II) acetate‐catalyzed aerobic oxidative amination. A library of 3‐aroylimidazopyridines was synthesized from readily accessible chalcones and 2‐aminopyridines with high yields and regioselectivity. The reaction proceeds through a tandem Michael addition followed by an intramolecular oxidative amination. The successful application of this methodology for a gram‐scale reaction indicates its potential for bulk synthesis.

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