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Copper(II)‐Catalyzed Aerobic Oxidative Coupling between Chalcone and 2‐Aminopyridine via CH Amination: An Expedient Synthesis of 3‐Aroylimidazo[1,2‐ a ]pyridines
Author(s) -
Monir Kamarul,
Kumar Bagdi Avik,
Mishra Subhajit,
Majee Adinath,
Hajra Alakananda
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300900
Subject(s) - chemistry , amination , oxidative phosphorylation , intramolecular force , catalysis , regioselectivity , 2 aminopyridine , organic chemistry , oxidative coupling of methane , combinatorial chemistry , copper , tandem , biochemistry , materials science , composite material
A simple and efficient protocol has been developed for the synthesis of 3‐aroylimidazopyridines via copper(II) acetate‐catalyzed aerobic oxidative amination. A library of 3‐aroylimidazopyridines was synthesized from readily accessible chalcones and 2‐aminopyridines with high yields and regioselectivity. The reaction proceeds through a tandem Michael addition followed by an intramolecular oxidative amination. The successful application of this methodology for a gram‐scale reaction indicates its potential for bulk synthesis.