A Versatile Metal‐Free Intermolecular Aminochlorination of Alkenes | Zendy

Martínez Claudio | Zendy; Muñiz Kilian | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A Versatile Metal‐Free Intermolecular Aminochlorination of Alkenes

Author(s) -

Martínez Claudio,

Muñiz Kilian

Publication year - 2014

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201300880

Subject(s) - chemistry , intermolecular force , protonation , acetic acid , stoichiometry , structural isomer , metal , reaction conditions , combinatorial chemistry , organic chemistry , molecule , catalysis , ion

New reaction conditions for the rapid and productive intermolecular aminochlorination reaction of alkenes using a combination of chloramine‐T and a Brønstedt acid are described. Upon simple protonation of chloramine‐T, conditions for a mild and selective aminochlorination are obtained. In addition, the reaction can proceed to form either of the two possible regioisomers, depending on whether a stoichiometric amount of such an acid activator or acetic acid is used as solvent. The reaction is operative for all different classes of alkenes. A total of over 50 examples is presented to illustrate this concept.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research