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Brønsted Acid‐Catalyzed Straightforward Synthesis of Benzo[ b ]carbazoles from 2,3‐Unsubstituted Indoles
Author(s) -
Suárez Anisley,
GarcíaGarcía Patricia,
FernándezRodríguez Manuel A.,
Sanz Roberto
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300868
Subject(s) - chemistry , benzaldehyde , regioselectivity , brønsted–lowry acid–base theory , catalysis , combinatorial chemistry , organic chemistry , stereochemistry
Described is a general and efficient synthesis of valuable benzo[ b ]carbazoles by Brønsted acid‐catalyzed reactions between simple C‐2,C‐3‐unsubstituted indoles and ortho ‐[α‐(hydroxy)benzyl]benzaldehyde acetals. Highly selective migration processes are involved as key steps in the overall cascade sequence that involves the one‐pot formation of two new bonds and a cycle in a regioselective fashion.