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Transition Metal‐Mediated Direct CH Arylation of Heteroarenes Involving Aryl Radicals
Author(s) -
Bonin Hélène,
Sauthier Mathieu,
Felpin FrançoisXavier
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300865
Subject(s) - chemistry , radical , aryl , transition metal , sulfur , photochemistry , combinatorial chemistry , metal , nitrogen , oxygen , organic chemistry , catalysis , alkyl
This review gives an overview of the generation of aryl radicals, mediated by transition metals, and their use for the CH arylation of heteroarenes. The different sources of aromatic derivatives able to generate aryl radicals via a metal‐assisted reduction or oxidation are discussed, with a critical view of the developed systems. The radical arylations of nitrogen‐, oxygen‐ or sulfur‐containing heterocycles are then described and mechanistic considerations are discussed as well.