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Silver(I)‐Catalyzed Conia‐Ene Reaction: Synthesis of 3‐Pyrrolines via a 5‐ endo ‐ dig Cyclization
Author(s) -
Boominathan Siva Senthil Kumar,
Hu WanPing,
Senadi Gopal Chandru,
Wang JehJeng
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300844
Subject(s) - chemistry , dig , catalysis , ene reaction , scope (computer science) , combinatorial chemistry , substrate (aquarium) , transformation (genetics) , base (topology) , medicinal chemistry , stereochemistry , organic chemistry , computer science , programming language , mathematical analysis , biochemistry , oceanography , computer security , mathematics , gene , geology
A novel method has been developed for the synthesis of 3‐pyrrolines from β‐ketopropargylamines via a 5‐ endo ‐ dig carbocyclization. This transformation involves a silver‐catalyzed Conia‐ene type reaction tolerating broad substrate scope with good to excellent yields. Furthermore, this methodology has been extended for the construction of 2‐substituted pyrroles under base‐mediated conditions.