Premium
Synthesis of 2‐Acylthiophenes by Palladium‐Catalyzed Addition of Thiophenes to Nitriles
Author(s) -
Jiang TaoShan,
Wang GuanWu
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300843
Subject(s) - chemistry , palladium , catalysis , bipyridine , organic chemistry , coupling reaction , combinatorial chemistry , crystal structure
A direct synthesis of 2‐acylthiophenes has been developed through palladium‐catalyzed addition of thiophenes to nitriles. The reaction proceeded well under the palladium(II) acetate/2,2′‐bipyridine system and using D ‐(+)‐camphorsulfonic acid as the additive. In addition, the obtained 2‐acylthiophenes could undergo further coupling reactions to generate novel products.