Premium
Synthesis of 2‐Acylthiophenes by Palladium‐Catalyzed Addition of Thiophenes to Nitriles
Author(s) -
Jiang TaoShan,
Wang GuanWu
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300843
Subject(s) - chemistry , palladium , catalysis , bipyridine , organic chemistry , coupling reaction , combinatorial chemistry , crystal structure
A direct synthesis of 2‐acylthiophenes has been developed through palladium‐catalyzed addition of thiophenes to nitriles. The reaction proceeded well under the palladium(II) acetate/2,2′‐bipyridine system and using D ‐(+)‐camphorsulfonic acid as the additive. In addition, the obtained 2‐acylthiophenes could undergo further coupling reactions to generate novel products.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom