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Palladium‐Catalyzed Intermolecular C‐2 Alkenylation of Indoles Using Oxygen as the Oxidant
Author(s) -
Yan ZhaoLei,
Chen WenLiang,
Gao YaRu,
Mao Shuai,
Zhang YanLei,
Wang YongQiang
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300811
Subject(s) - chemistry , palladium , stereoselectivity , intermolecular force , catalysis , oxygen , regioselectivity , oxygen atom , medicinal chemistry , organic chemistry , photochemistry , stereochemistry , molecule
A general and efficient palladium‐catalyzed intermolecular direct C‐2 alkenylation of indoles using oxygen as the oxidant has been developed. The reaction is of complete regio‐ and stereoselectivity. All products are E ‐isomers at the C‐2‐position with no Z ‐isomers and 3‐substituted products were detected.