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Transition Metal‐Free Regioselective C‐3 Amidation of Indoles with N ‐Fluorobenzenesulfonimide
Author(s) -
Liu HaiHong,
Wang Yi,
Deng Guojun,
Yang Luo
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300767
Subject(s) - regioselectivity , chemistry , combinatorial chemistry , transition metal , catalysis , organic chemistry
A direct transition metal‐free regioselective C‐3 amidation of indoles has been developed with the commercially available N ‐fluorobenzenesulfonimide (NFSI) as the amino source under external oxidant‐free conditions. This amidation requires only a catalytic amount of base and exhibits excellent functional group tolerance and regioselectivity. The C‐3 regioselectivity was proposed to realize by a free radical mechanism.