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Total Synthesis of (±)‐1‐Acetylaspidoalbidine and (±)‐1‐Methylaspidospermidine
Author(s) -
Jin Jian,
Qiu Fayang G.
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300756
Subject(s) - chemistry , tryptamine , stereoselectivity , total synthesis , tandem , ring (chemistry) , michael reaction , stereochemistry , organocatalysis , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , biochemistry , materials science , composite material
(±)‐1‐Acetylaspidoalbidine and (±)‐1‐methylaspidospermidine were synthesized from protected tryptamine through the combination of an organocatalytic Diels–Alder reaction, a tandem stereoselective ring‐opening reduction, and a double Michael addition.