Palladium/Copper Complexes Co‐Catalyzed Highly Enantioselective Ring Opening Reaction of Azabenzonorbornadienes with Terminal Alkynes | Zendy

Fan Baomin | Zendy; Li Sifeng | Zendy; Chen Hualei | Zendy; Lu Zhiwu | Zendy; Liu Shanshan | Zendy; Yang Qingjing | Zendy; Yu Lu | Zendy; Xu Jianbin | Zendy; Zhou Yongyun | Zendy; Wang Jun | Zendy

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Palladium/Copper Complexes Co‐Catalyzed Highly Enantioselective Ring Opening Reaction of Azabenzonorbornadienes with Terminal Alkynes

Author(s) -

Fan Baomin,

Li Sifeng,

Chen Hualei,

Lu Zhiwu,

Liu Shanshan,

Yang Qingjing,

Yu Lu,

Xu Jianbin,

Zhou Yongyun,

Wang Jun

Publication year - 2013

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201300748

Subject(s) - chemistry , palladium , enantioselective synthesis , trifluoromethanesulfonate , copper , catalysis , ring (chemistry) , substrate (aquarium) , medicinal chemistry , combinatorial chemistry , binap , metal , polymer chemistry , stereochemistry , organic chemistry , oceanography , geology

A chiral palladium/copper (Pd/Cu) co‐catalytic system which could enable asymmetric ring opening reaction of azabenzonorbornadienes with terminal alkynes is reported. This system comprises palladium(II) acetate [Pd(OAc) 2 ]/( R )‐xyl‐Binap and copper(I) triflate (CuOTf). A good substrate scope was found, with excellent enantioselective outcomes (up to >99.9 % ee ). A reaction mechanism involving two metal complexes is also proposed.

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