Premium
Suzuki–Miyaura Cross‐Coupling under Solvent‐Free Conditions
Author(s) -
Asachenko Andrey F.,
Sorochkina Kristina R.,
Dzhevakov Pavel B.,
Topchiy Maxim A.,
Nechaev Mikhail S.
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300741
Subject(s) - chemistry , palladium , aryl , triphenylphosphine , pinacol , solvent , catalysis , coupling reaction , suzuki reaction , halide , chloride , organic chemistry , medicinal chemistry , alkyl
A solvent‐free reaction protocol for Suzuki–Miyaura cross‐couplings was developed. (Hetero)aryl bromides and chlorides are coupled with pinacol arylboronates in high yields. The reaction is catalyzed by conventional bis(triphenylphosphine)palladium(II) chloride [(PPh 3 ) 2 PdCl 2 ] and/or palladium(II) acetate/SPhos [Pd(OAc) 2 /SPhos] under air.