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Stereocontrol in Palladium‐Catalyzed Propargylic Substitutions: Kinetic Resolution to give Enantioenriched 1,5‐Enynes and Propargyl Acetates
Author(s) -
Ardolino Michael J.,
Eno Meredith S.,
Morken James P.
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300720
Subject(s) - propargyl , chemistry , kinetic resolution , enyne , palladium , catalysis , combinatorial chemistry , organic chemistry , enantioselective synthesis
Kinetic resolution during the catalytic allyl‐propargyl cross‐coupling with chiral starting materials can be accomplished with a chiral palladium catalyst. These reactions offer ready access to enantiomerically enriched enyne products from simple, readily available starting materials.