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Mesoporous Niobium Oxide Spheres as an Effective Catalyst for the Transamidation of Primary Amides with Amines
Author(s) -
Ghosh Subhash Chandra,
Li Cheng Chao,
Zeng Hua Chun,
Ngiam Joyce S. Y.,
Seayad Abdul M.,
Chen Anqi
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300717
Subject(s) - chemistry , primary (astronomy) , catalysis , niobium , mesoporous material , oxide , niobium oxide , combinatorial chemistry , alkyl , organic chemistry , physics , astronomy
Mesoporous niobium oxide spheres (MNOS), conveniently prepared by a novel antisolvent precipitation approach, have been shown to be an effective catalyst for the transamidation of primary amides with amines. This novel transamidation can be efficiently carried out under solvent‐free conditions and is applicable to a wide range of primary amides and amines to provide N ‐alkyl amides in good to excellent yields. The catalyst is highly stable and reusable. The application of this transamidation reaction has been demonstrated in the synthesis of antidepressant drug moclobemide and other drug‐like compounds.